Combinatorial co-expression of pheromone receptors, V2Rs

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Co-expression of putative pheromone receptors in the sensory neurons of the vomeronasal organ.

Two large and divergent families of G-protein-coupled receptors (V1Rs and V2Rs) are expressed in subsets of neurons in the vomeronasal organ. These receptors are likely to mediate pheromone responses, but it appears that many V2R genes may encode expressed pseudogenes rather than functional proteins. Therefore we have raised antibodies to representative V2Rs and show labeling of vomeronasal neu...

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The vomeronasal organ (VNO) of the mouse has two neuronal compartments expressing distinct families of pheromone receptors, the V1Rs and the V2Rs. We report here that two families of major histocompatibility complex (MHC) class Ib molecules, the M10 and the M1 families, show restricted expression in V2R-expressing neurons. Our data suggest that neurons expressing a given V2R specifically co-exp...

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ژورنال

عنوان ژورنال: Journal of Neurochemistry

سال: 2007

ISSN: 0022-3042,1471-4159

DOI: 10.1111/j.1471-4159.2007.04877.x